Dynamic Chronological Changes in Serum Triglycerides Are Associated With the Time Point for Non-alcoholic Fatty Liver Disease Development in the Nationwide Korean Population Cohort

Background: We investigated the effects of anthropometric, laboratory, and lifestyle factors on development non-alcoholic fatty liver disease (NAFLD) in a nationwide, population-based, 4-year retrospective cohort. Methods: The propensity score-matched study control groups contained 1,474 subjects who had data Korean National Health Insurance Service-National Sample Cohort 2009, 2011, 2013. NAFLD was defined using medical records diagnosis confirmed by primary clinicians meeting two previously validated prediction models. Chronological changes anthropometric variables, laboratory results, during periods were compared between patient order to find out parameters with consistent dynamics pre-NAFLD stage which as period just before development. Results: Among 5 10 3 factors, prominent chronological decremental serum triglycerides consistently observed stage, although degrees more predominant men (−9.46 mg/dL) than women (−5.98 mg/dL). Furthermore, weight waist circumference noticeable only (+0.36 kg +0.9 cm for circumference, respectively), suggest gender difference NAFLD. Conclusion: Early screening strategies people abrupt predict progression is recommended.